T lymphocyte responses against human parvovirus B19: small virus, big response
T lymphocyte responses against human parvovirus B19: small virus, big response
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DOI：
10.1016/s0369-8114(02)00306-1
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发表时间：
2002-06-01
影响因子：
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通讯作者：
Oxenius, A
中科院分区：
文献类型：
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作者：
Klenerman, P;Tolfvenstam, T;Oxenius, A
细小病毒B19可引起体液和细胞免疫应答。近年来，在确定病毒特异性CD 8 + T淋巴细胞应答的频率、肽靶点和功能方面取得了一些进展。到目前为止，已经研究了来自NS 1蛋白的单个HLA B35限制性表位，但显然存在其他表位。使用干扰素-γ ELISpot测定和HLA I类肽四聚体，在健康血清阳性个体中检测到令人惊讶的大的持续应答。类似的技术可用于探索CD 4 + T细胞表位，尽管目前可用的细节较少。针对整个B19基因组（细小病毒“免疫组”）的细胞免疫反应的绘图现在是可能的，如果一致地发现类似的大群体，这可能会产生对B19相关疾病的正常免疫控制和异常的重要见解。(C)2002年，Elsevier SAS科学与医学版。
Parvovirus B19 elicits both humoral and cellular immune responses. Recently some advances have been made in determining the frequencies, peptide targets and function of virus-specific CD8+ T lymphocyte responses. A single HLA B35-restricted epitope derived from the NS1 protein has been studied so far, but others clearly exist. Surprisingly large, persistent responses have been detected in healthy seropositive individuals, using interferon-gamma ELISpot assays and HLA class I peptide tetramers. Similar techniques are available for exploration of the CD4+ T cell epitopes, although less detail is currently available. Mapping of cellular immune responses against the entire B19 genome (the parvovirus "Immunome") is now possible and if similarly large populations are found consistently, this could yield important insight into normal immunological control and abnormalities in B19-related disease. (C) 2002 Editions scientifiques et medicales Elsevier SAS.