ASSOCIATION OF BODY-WEIGHT WITH RECURRENT CANCER OF BREAST
ASSOCIATION OF BODY-WEIGHT WITH RECURRENT CANCER OF BREAST
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DOI：
10.1002/1097-0142(197804)41:4
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发表时间：
1978-01-01
期刊：
影响因子：
6.2
通讯作者：
RIMM, AA
中科院分区：
文献类型：
--
作者：
DONEGAN, WL;HARTZ, AJ;RIMM, AA
乳腺癌根治术后复发与术前体重有关。在观察长达24年的患者中，无腋窝淋巴结转移且体重在130磅或以下的患者累积无复发生存率上级优于体重较重的患者。该优势与绝经状态、临床分期或肿瘤大小的显著差异无关。高脂肪饮食和庞大的体重在流行病学上与乳腺癌的高风险有关。无论涉及何种生物学机制，都可能促进潜在治愈性手术后残留肿瘤的生长。饮食和减肥可能是改善早期乳腺癌患者预后的经验手段。
Recurrence of carcinoma of the breast after radical mastectomy was associated with preoperative body wt. among patients observed for up to 24 yr. Patients who had no axillary lymph node metastases and weighed 130 lb or less had an accumulative recurrence free survival superior to that of heavier patients. The advantage was unassociated with significant differences in menopausal status, clinical stage or tumor size. High fat diet and large body mass were linked epidemiologically with high risk for breast cancer. Whatever biologic mechanisms are involved may also promote growth of residual tumor after potentially curative surgery. Diet and weight reduction may represent empirical means for improving the prognosis of heavy individuals with early stages of breast cancer.