The effect of glycaemic control and glycaemic variability on mortality in patients hospitalized with congestive heart failure
The effect of glycaemic control and glycaemic variability on mortality in patients hospitalized with congestive heart failure
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DOI：
10.1002/dmrr.1155
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发表时间：
2011-01-01
影响因子：
8
通讯作者：
Osei, Kwame
中科院分区：
文献类型：
--
作者：
Dungan, Kathleen M.;Binkley, Philip;Osei, Kwame
背景糖尿病和慢性心力衰竭是住院患者常见的合并症，但两种疾病患者的血糖控制、血糖变异性和死亡率之间的关系尚不清楚。方法：我们使用行政资料对频繁进行血糖评估的诊断为CHF的患者进行回顾性分析。将TWMG与其他血糖控制指标以及血糖变异性的时间加权指标——血糖不稳定指数进行比较。结果是医院死亡率。结果共纳入748例患者。时间加权平均葡萄糖高于未调整的平均葡萄糖（137 +/- 44.7 mg/dL vs 167 +/- 54.9 mg/dL, p < 0.001），部分原因是在较高的葡萄糖水平下较短的采样间隔。低血糖，定义为葡萄糖水平
Background Diabetes and CHF are common comorbidities in hospitalized patients but the relationship between glycaemic control, glycaemic variability, and mortality in patients with both conditions is unclear.Methods We used administrative data to retrospectively identify patients with a diagnosis of CHF who underwent frequent glucose assessments. TWMG was compared with other measures of glycaemic control and a time-weighted measure of glycaemic variability, the glycaemic lability index. The outcome was hospital mortality.Results A total of 748 patients were included in the final analysis. Time-weighted mean glucose was higher than unadjusted mean glucose (137 +/- 44.7 mg/dL versus 167 +/- 54.9, p < 0.001), due in part to shorter sampling intervals at higher glucose levels. Hypoglycaemia, defined as a glucose level