Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering
Effect of Chitin Nanofibrils on Biocompatibility and Bioactivity of the Chitosan-Based Composite Film Matrix Intended for Tissue Engineering
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DOI：
10.3390/ma12111874
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发表时间：
2019-06-01
期刊：
影响因子：
3.4
通讯作者：
Morganti, Pierfrancesco
中科院分区：
文献类型：
--
作者：
Smirnova, Natalia V.;Kolbe, Konstantin A.;Morganti, Pierfrancesco
本文讨论了基于壳聚糖的膜基质的机械和物理化学性质，以及通过添加甲壳素纳米纤维来优化这些性质的可能性。结果表明，随着甲壳素纳米纤维作为填料的引入，复合材料的机械稳定性增加。通过改变几丁质纳米原纤维的浓度，可以获得一系列具有不同生物活性特性的样品，用于人皮肤成纤维细胞的生长。基于壳聚糖和5wt%几丁质纳米原纤维的纳米复合材料的膜基质具有与人皮肤成纤维细胞培养相关的机械和物理化学性质和生物活性的最佳平衡。
This paper discusses the mechanical and physicochemical properties of film matrices based on chitosan, as well as the possibility of optimizing these properties by adding chitin nanofibrils. It is shown that with the introduction of chitin nanofibrils as a filler, the mechanical stability of the composite materials increases. By varying the concentration of chitin nanofibrils, it is possible to obtain a spectrum of samples with different bioactive properties for the growth of human dermal fibroblasts. Film matrices based on the nanocomposite of chitosan and 5 wt % chitin nanofibrils have an optimal balance of mechanical and physicochemical properties and bioactivity in relation to the culture of human dermal fibroblasts.