Contribution of muscle afferents to prolonged flexion withdrawal reflexes in human spinal cord injury.
Contribution of muscle afferents to prolonged flexion withdrawal reflexes in human spinal cord injury.
复制标题
肌肉传入对人类脊髓损伤中长时间屈曲撤回反射的贡献。
DOI：
10.1152/jn.00152.2004
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Schmit,BD
中科院分区：
文献类型：
--
作者：
Hornby,TG;Tysseling-Mattiace,VM;Benz,EN;Schmit,BD
研究了人脊髓损伤（SCI）后，力敏肌传入神经对延长的屈缩反射或屈肌痉挛的作用。在三个独立的实验条件下，屈曲反射被触发的SCI患者使用列车的电刺激在脚和小腿，并通过肌内（IM）电刺激引起的反射进行比较。在第一个实验中，屈曲反射引起使用IM刺激的胫骨前肌（TA）在大多数受试者的测试。峰值等距踝关节髋关节扭矩的比例在IM触发的反射成比例地类似于那些诱发的电脚或小腿刺激，虽然潜伏期发作和峰值屈曲扭矩显着更长的IM刺激。在第二个实验中，改变IM TA刺激的幅度和频率以改变刺激诱导的肌肉扭矩。峰值踝关节和髋关节的屈曲反射反应过程中产生的扭矩在更大程度上与刺激诱导的肌肉扭矩相比，调制的刺激参数。在第三个实验系列中，IM刺激腓肠肌（GS）引起屈曲反射在大约一半的受试者测试。综合数据表明，IM TA刺激后，刺激诱导的肌肉收缩对屈肌反射行为的幅度和潜伏期具有潜在的显著作用。IM GS刺激后的结果表明，也可以引起多关节屈曲反射，尽管程度低于IM TA刺激。
The contribution of force-sensitive muscular afferents to prolonged flexion withdrawal reflexes, or flexor spasms, after human spinal cord injury (SCI) was investigated. In three separate experimental conditions, flexion reflexes were triggered in subjects with SCI using trains of electrocutaneous stimuli delivered at the foot and lower leg and compared with reflexes elicited via intramuscular (IM) electrical stimuli. In the first experiment, flexion reflexes were elicited using IM stimuli to the tibialis anterior (TA) in the majority of subjects tested. The ratio of peak isometric ankle to hip torques during IM-triggered reflexes were proportionally similar to those evoked by electrocutaneous foot or shank stimulation, although the latency to onset and peak flexion torques were significantly longer with IM stimulation. In the second experiments, the amplitude and frequency of IM TA stimulation were varied to alter the stimulus-induced muscle torque. Peak ankle and hip torques generated during the flexion reflex responses were correlated to a greater extent with stimulus-induced muscle torques as compared with the modulated stimulus parameters. In the third experimental series, IM stimuli delivered to the gastrocnemius (GS) elicited flexion reflexes in approximately half of the subjects tested. The combined data indicate a potentially prominent role of the stimulus-induced muscle contraction to the magnitude and latency of flexor reflex behaviors after IM TA stimulation. Results after IM GS stimulation indicate multi-joint flexion reflexes can also be elicited, although to a lesser extent than IM TA stimulation.