Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis
Neurocognitive sequelae in African American and Caucasian children with multiple sclerosis
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DOI：
10.1212/wnl.0b013e318200d7b9
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发表时间：
2010-12-07
期刊：
影响因子：
9.9
通讯作者：
Ackerson, J.
中科院分区：
文献类型：
--
作者：
Ross, K. A.;Schwebel, D. C.;Ackerson, J.
目的：研究非裔美国人（AA）和高加索人（CA）儿童型多发性硬化症（POMS）患者之间特定领域的神经认知差异。方法：对每个受试者进行广泛的神经心理学测试，包括所有主要认知功能领域的测试。计算种族和测试表现之间的点二列相关性。显着的相关性进行了随访，分层多元回归分析，占临床和人口统计学变量之前，检查ethnic differences.Results：42例POMS患者，包括20 AA和22 CA科目进行了评估。这些队列在年龄、性别、社会经济地位、疾病持续时间、残疾评分、免疫球蛋白G指数或疾病前2年复发次数方面没有差异。保留这些变量中的一些作为协变量的分层回归分析中，AA队列表现较差的措施的语言（p < 0.001）和复杂的注意（p < 0.01）比他们的CA peer.Conclusion：AA患者POMS可能是在较高的风险，不利的认知影响的语言和复杂的注意领域。认知病理学的纵向特征对于制定有效的干预策略以延长POMS队列的认知功能至关重要。神经病学（R）2010;75：2097-2102
Objective: To examine domain-specific neurocognitive differences between African American (AA) and Caucasian (CA) patients with pediatric-onset multiple sclerosis (POMS).Methods: An extensive battery of neuropsychological tests was given to each subject, including tests in all major domains of cognitive function. Point-biserial correlations between ethnicity and test performance were computed. Significant correlations were followed up with hierarchical multiple regression analysis, accounting for clinical and demographic variables before examining ethnic differences.Results: Forty-two patients with POMS including 20 AA and 22 CA subjects were assessed. The cohorts did not differ in age, gender, socioeconomic status, disease duration, disability score, immunoglobulin G index, or number of relapses in the first 2 years of disease. Retaining some of these variables as covariates in the hierarchical regression analysis, the AA cohort performed worse on measures of language (p < 0.001) and complex attention (p < 0.01) than their CA peers.Conclusion: AA patients with POMS may be at higher risk for adverse cognitive impact in the areas of language and complex attention. Longitudinal characterization of cognitive pathology is critical for the development of effective intervention strategies to prolong cognitive functioning in POMS cohorts. Neurology (R) 2010;75:2097-2102