Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?
Biological therapies for cardiac arrhythmias: can genes and cells replace drugs and devices?
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DOI：
10.1161/circresaha.109.212936
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发表时间：
2010-03-05
影响因子：
20.1
通讯作者：
Marbán E
中科院分区：
文献类型：
--
作者：
Cho HC;Marbán E
心律失常反映了冲动产生和/或传导的失败。除了产生选择性心内膜破坏的消融方法外，目前的治疗方法是非特异性和/或姑息性的。在了解潜在生物学方面的进展为新的替代方案开辟了前景。本文综述了以基因和细胞为基础的治疗纠正心律紊乱的技术现状。我们从这种方法的基本原理开始，简要讨论了解决快速性心律失常的一些方面的努力，并回顾了创造一种生物起搏器来治疗缓慢性心律失常的进展。所获得的洞察力使该领域更接近于在治疗节律紊乱方面从设备和药物转向生物制剂。
Cardiac rhythm disorders reflect failures of impulse generation and/or conduction. With the exception of ablation methods that yield selective endocardial destruction, present therapies are nonspecific and/or palliative. Progress in understanding the underlying biology opens up prospects for new alternatives. This article reviews the present state of the art in gene- and cell-based therapies to correct cardiac rhythm disturbances. We begin with the rationale for such approaches, briefly discuss efforts to address aspects of tachyarrhythmia, and review advances in creating a biological pacemaker to cure bradyarrhythmia. Insights gained bring the field closer to a paradigm shift away from devices and drugs, and toward biologics, in the treatment of rhythm disorders.