Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates
Chloroquinolines block antibiotic efflux pumps in antibiotic-resistant Enterobacter aerogenes isolates
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DOI：
10.1016/j.ijantimicag.2006.03.010
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发表时间：
2006-06-01
影响因子：
10.8
通讯作者：
Barbe, Jacques
中科院分区：
文献类型：
--
作者：
Ghisalberti, Didier;Mahamoud, Abdallah;Barbe, Jacques
外排机制通过排出有毒化合物来保护细菌细胞，并积极促进细菌的多药耐药。抑制外排泵的药物对于控制多重耐药细菌感染很有意义。在这里，我们报告了新的氯喹啉衍生物的效果，使耐药产气肠杆菌明显更容易受到结构上无关的抗生素的影响。此外，其中一些氯喹啉类药物会增加细胞内氯霉素的浓度。在这项工作中测试的一些分子能够抑制主外排泵(AcrAB-TolC)，该泵与产气假单胞菌的耐药性有关。(C)2006年爱思唯尔公司和国际化疗学会。版权所有。
Efflux mechanisms protect bacterial cells by pumping Out toxic Compounds and actively contribute to bacterial multidrug resistance. Agents inhibiting efflux pumps are of interest for the control of multidrug-resistant bacterial infections. Herein we report the effects of new chloroquinoline derivatives that render resistant Enterobacter aerogenes isolates noticeably more susceptible to structurally unrelated antibiotics. In addition, some of these chloroquinolines increase the intracellular concentration of chloramphenicol. Some of the molecules tested in this work are able to inhibit the main efflux pump (AcrAB-TolC), which is involved in E. aerogenes antibiotic resistance. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.