Cationic comb-type copolymers for boosting DNA-fueled nanomachines.
Cationic comb-type copolymers for boosting DNA-fueled nanomachines.
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DOI：
10.1021/nl0626232
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发表时间：
2007
期刊：
影响因子：
10.8
通讯作者：
S. Choi;Naoki Makita;S. Inoue;Charles Lesoil;A. Yamayoshi;Arihiro Kano;T. Akaike;A. Maruyama
中科院分区：
文献类型：
--
作者：
S. Choi;Naoki Makita;S. Inoue;Charles Lesoil;A. Yamayoshi;Arihiro Kano;T. Akaike;A. Maruyama
为了更好地应用和发展DNA纳米机器，其响应动力学、产量和序列选择性需要改进。此外，DNA纳米机器目前在操作条件方面存在一些限制。在这里，我们表明，一个简单的添加阳离子梳型共聚物，聚（L-赖氨酸）-接枝-葡聚糖，产生强大的和快速的响应DNA纳米机器在温和的条件下，包括生理相关的条件下，即使在非常低的链浓度（纳摩尔每升的范围），通过杂交稳定和DNA链交换加速。
For the better applications and developments of DNA nanomachines, their responding kinetics, output, and sequence-selectivity need to be improved. Furthermore, the DNA nanomachines currently have several limitations in operating conditions. Here we show that a simple addition of a cationic comb-type copolymer, poly(l-lysine)-graft-dextran, produces the robust and quick responses of DNA nanomachines under moderate conditions including physiologically relevant conditions even at very low strand concentrations (nanomoles per liter range) through hybrid stabilization and DNA strand exchange acceleration.