Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods.
Influence of maternal care on the developing brain: Mechanisms, temporal dynamics and sensitive periods.
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DOI：
10.1016/j.yfrne.2015.11.001
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发表时间：
2016-01
影响因子：
7.4
通讯作者：
Champagne FA
中科院分区：
文献类型：
--
作者：
Curley JP;Champagne FA
母亲护理的差异可能会导致后代不同的发育轨迹，并对神经内分泌功能和行为表型产生影响。对与母婴相互作用相关的长期结果的研究表明，将产妇护理变化的经历与这些神经生物学后果联系起来的机制很复杂。通过整合遗传学、分子、细胞、神经解剖学和神经内分泌的方法，我们在理解这些复杂的通路方面取得了重大进展。在这篇综述中，我们将考虑产妇护理对男性和女性后代发育的影响，特别是时间和机制问题。确定产妇护理的敏感期和作为产妇护理结果的分子和神经内分泌变化的时间动力学是机理研究中的关键一步。
Variation in maternal care can lead to divergent developmental trajectories in offspring with implications for neuroendocrine function and behavioral phenotypes. Study of the long-term outcomes associated with mother-infant interactions suggests complex mechanisms linking the experience of variation in maternal care and these neurobiological consequences. Through integration of genetic, molecular, cellular, neuroanatomical, and neuroendocrine approaches, significant advances in our understanding of these complex pathways have been achieved. In this review, we will consider the impact of maternal care on male and female offspring development with a particular focus on the issues of timing and mechanism. Identifying the period of sensitivity to maternal care and the temporal dynamics of the molecular and neuroendocrine changes that are a consequence of maternal care represents a critical step in the study of mechanism.