Epidemiological analysis of the early 38 fatalities in Hubei,China, of the coronavirus disease 2019
Epidemiological analysis of the early 38 fatalities in Hubei,China, of the coronavirus disease 2019
复制标题
DOI：
10.7189/jogh.10.011004
复制
发表时间：
2020-06-01
影响因子：
7.2
通讯作者：
Zang, Shuang
中科院分区：
文献类型：
--
作者：
Chen, Yifei;Zhao, Meizhen;Zang, Shuang
背景 自 2019 年底在中国湖北省出现 2019 冠状病毒病（COVID-19）以来，它已在全球肆虐，导致死亡人数仍在快速增长，在不到两个月的时间里远远超过了严重急性呼吸系统综合症（SARS）的死亡人数。由于缺乏证据表明哪些人群更有可能在病例中发展为重症，我们研究了第一批死亡病例，旨在补充现有证据并减少人群的恐慌。方法我们前瞻性地收集了第一批死亡病例的人口和临床数据：38 名死亡病例。湖北省卫健委和中央电视台新闻中心官方微博于2020年1月9日至1月24日期间对死亡病例进行了公开。从性别和年龄特征、基础疾病、死亡时间、发病初期症状和入院时四个方面对死亡病例进行描述。结果 38例死亡病例中，男性占71.05%，女性占28.95%，中位年龄70岁年（四分位数间距 (IQR)= 65-81）。 66-75岁人群占比最大。 25例有慢性病史。首次出现症状和死亡之间的中位时间为 12.50 天 (IQR = 10.00-16.25)，而入院和死亡之间的中位时间为 8.50 (IQR = 5.00-12.00) 天。在56岁以上的人群中，首次出现症状到死亡之间的时间随着年龄的增长而缩短，入院到死亡之间的时间也随着年龄的增长而缩短，但在85岁以上的人群中，后者再次增加。主要首发症状为发热（52.63%）、咳嗽（31.58%）、呼吸困难（23.68%）、肌痛、乏力（15.79%）。结论死亡病例中，有基础疾病和65岁以上老年人占多数。随着年龄的增长，首次出现症状和死亡之间的时间会缩短。在所有年龄段中，男性死亡人数最多。
Background Since the emergence of coronavirus disease 2019 (COVID-19) in Hubei province of China by the end of 2019, it has burned its way across the globe, resulting in a still fast-growing death toll that far exceeded those from severe acute respiratory syndrome (SARS) in less than two months. As there is a paucity of evidence on which population is more likely to progress into severe conditions among cases, we looked into the first cluster of death cases, aiming to add to current evidence and reduce panic among the population.Methods We prospectively collected the demographic and clinical data of the first :38 fatalities whose. information was made public by the Health Commission of Hubei province and the official Weibo account of China Central Television news center, starting from 9 January through 24 January 2020. The death cases were described from four aspects (gender and age characteristics, underlying diseases, the time course of death, symptoms at the incipience of illness and hospital admission).Results Among the 38 fatalities, 71.05% were male, and 28.95% were female, with the median age of 70 years (interquartile range (IQR)= 65-81). Persons aged 66-75 made up the largest share. Twenty-five cases had a history of chronic diseases. The median time between the first symptoms and death was 12.50 days (IQR =10.00-16.25), while the median time between the admission and death was 8.50 (IQR = 5.00-12.00) days. In persons aged over 56 years, the time between the first symptoms and death decreased with age, and so did the time between the admission and death, though the latter increased again in persons aged over 85 years. The major first symptoms included fever (52.63%), cough (31.58%), dyspnea (23.68%), myalgia and fatigue (15.79%).Conclusions Among the death cases, persons with underlying diseases and aged over 65 made up the majority. The time between the first symptoms and death decreased with the advanced age. In all the age groups, males dominated the fatalities.