The human vaginal bacterial biota and bacterial vaginosis.
The human vaginal bacterial biota and bacterial vaginosis.
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DOI：
10.1155/2008/750479
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发表时间：
2008
影响因子：
--
通讯作者：
Fredricks DN
中科院分区：
文献类型：
--
作者：
Srinivasan S;Fredricks DN
人类阴道的细菌生物群对妇女及其新生儿的健康有着深远的影响。阴道微生物群的变化与几种不良健康结果有关，包括早产，盆腔炎和艾滋病毒感染。不依赖于培养的分子方法为这一重要生态位的细菌多样性提供了新的见解，特别是在患有常见疾病细菌性阴道病（BV）的女性中。PCR方法显示，BV女性患者的阴道细菌群落复杂，包括许多难养菌，特别是拟杆菌门和放线菌门。健康的女性大多数是乳酸杆菌的殖民地，如卷曲乳杆菌，詹氏乳杆菌和惰性乳杆菌，尽管可能存在各种其他细菌。BV的微生物学是异质性的。在一些BV受试者中，阴道上皮上存在阴道加德纳菌和阴道变形菌，这表明生物膜可能导致这种情况。
The bacterial biota of the human vagina can have a profound impact on the health of women and their neonates. Changes in the vaginal microbiota have been associated with several adverse health outcomes including premature birth, pelvic inflammatory disease, and acquisition of HIV infection. Cultivation-independent molecular methods have provided new insights regarding bacterial diversity in this important niche, particularly in women with the common condition bacterial vaginosis (BV). PCR methods have shown that women with BV have complex communities of vaginal bacteria that include many fastidious species, particularly from the phyla Bacteroidetes and Actinobacteria. Healthy women are mostly colonized with lactobacilli such as Lactobacillus crispatus, Lactobacillus jensenii, and Lactobacillus iners, though a variety of other bacteria may be present. The microbiology of BV is heterogeneous. The presence of Gardnerella vaginalis and Atopobium vaginae coating the vaginal epithelium in some subjects with BV suggests that biofilms may contribute to this condition.