PGE2 IS A MORE POTENT VASODILATOR OF LAMB DUCTUS-ARTERIOSUS THAN IS EITHER PGI2 OR 6-KETO PGF1-ALPHA
PGE2 IS A MORE POTENT VASODILATOR OF LAMB DUCTUS-ARTERIOSUS THAN IS EITHER PGI2 OR 6-KETO PGF1-ALPHA
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DOI：
10.1016/0090-6980(78)90028-x
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发表时间：
1978-01-01
影响因子：
2.9
通讯作者：
RUDOLPH, AM
中科院分区：
文献类型：
--
作者：
CLYMAN, RI;MAURAY, F;RUDOLPH, AM
体外实验表明，羔羊动脉导管可形成前列腺素PGE2、PGF2.alpha。， 6酮pgf1 α。（及其不稳定的前体PGI2）。研究了这些内源性前列腺素在暴露于pO2[氧张力]升高和吲哚美辛而收缩的离体羔羊动脉导管制剂上的相对效力。所有前列腺素（pgf2 . α除外）均使血管松弛。这与内源性前列腺素抑制血管响应O2收缩倾向的假设是一致的。然而，只有PGE2浓度低于10-8 m时，PGI2和6酮pgf1 - α使血管松弛。大约是PGE2活性的10-3和10-4倍。虽然PGE2已被观察到是羔羊动脉导管中前列腺素产生的次要产物，但该组织对PGE2的显著敏感性可能使其成为调节血管通畅的最重要的前列腺素。
It was shown in vitro that the lamb ductus arteriosus forms prostaglandins PGE2, PGF2.alpha., 6 keto PGF1.alpha. (and its unstable precursor PGI2). The relative potencies of these endogenous prostaglandins were investigated on isolated lamb ductus arteriosus preparations contracted by exposure to elevated pO2 [oxygen tension] and indomethacin. All the prostaglandins (except PGF2.alpha.) relaxed the vessel. This is consistent with the hypothesis that endogenous prostaglandins inhibit the tendency of the vessel to contract in response to O2. Only PGE2, however, relaxed the vessel at concentrations below 10-8 M. PGI2 and 6 keto PGF1.alpha. had approximately 10-3 and 10-4 times the activity of PGE2. Although PGE2 has been observed to be a minor product of prostaglandin production in the lamb ductus arteriosus, the tissue''s marked sensitivity to PGE2 might make it the most significant prostaglandin in regulating the patency of the vessel.