Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.
Association of IFN-γ : IL-10 Cytokine Ratio with Nonsegmental Vitiligo Pathogenesis.
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DOI：
10.1155/2015/423490
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发表时间：
2015
影响因子：
4
通讯作者：
Jahan P
中科院分区：
文献类型：
--
作者：
Ala Y;Pasha MK;Rao RN;Komaravalli PL;Jahan P
背景和目标。细胞因子调节免疫应答和炎症反应，在白癜风的色素脱失过程中起重要作用。本研究旨在估计印度非节段性白癜风患者和健康人血清中促炎性和抗炎性细胞因子、IFN-γ和IL-10的水平及其比值。方法。采集280例受试者血样，采用标准ELISA法测定血清IFN-γ和IL-10水平。结果。与对照组相比，非节段性白癜风患者的IFN-γ水平升高（12.4±3.2比9.9±4.4 pg/mL）， IL-10水平降低（9.3±1.7比11.5±5 pg/mL）。IFN-γ: IL-10比值与对照组比较差异有统计学意义（p < 0.05）。IFN-γ浓度和IFN-γ: IL-10比值在临床变异、疾病稳定性和社会习惯（吸烟和饮酒）方面存在显著差异，并与疾病持续时间呈正相关。白癜风家族史与IFN-γ: IL-10比值显著相关，但与个体水平无关。结论。血清IFN-γ与IL-10比值可作为非节段性白癜风的免疫学指标之一。这是第一个考虑与细胞因子水平比值有关的多个方面的研究。有必要进行类似的大样本研究，以证实我们的观察结果。
Background and Objectives. Cytokines regulate immune response and inflammation and play a crucial role in depigmentation process of vitiligo. The present study aimed to estimate the serum levels of pro- and anti-inflammatory cytokines, IFN-γ and IL-10, and their ratios in nonsegmental vitiligo patients and healthy individuals from India. Methods. Blood samples were collected from 280 subjects and serum IFN-γ and IL-10 levels were measured using standard ELISA. Results. Nonsegmental vitiligo patients showed increased levels of IFN-γ (12.4 ± 3.2 versus 9.9 ± 4.4 pg/mL) and decreased levels of IL-10 (9.3 ± 1.7 versus 11.5 ± 5 pg/mL) compared to controls. Ratio of IFN-γ : IL-10 differed significantly from patients to controls (p < 0.05). IFN-γ concentrations and IFN-γ : IL-10 ratio varied significantly with respect to clinical variants, disease stability, and social habits (smoking and alcohol consumption) and showed a positive correlation with disease duration. Family history of vitiligo was significantly associated with IFN-γ : IL-10 ratio but not with their individual levels. Conclusion. The ratio of IFN-γ : IL-10 serum levels may be considered as one of the promising immunological markers in nonsegmental vitiligo. This is the first study considering multiple aspects in relation to ratio of cytokine levels. Similar studies with large samples are warranted to confirm our observations.