Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
Chi and dLMO function antagonistically on Notch signaling through directly regulation of fng transcription.
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Chi 和 dLMO 通过直接调节 fng 转录对 Notch 信号发挥拮抗作用
DOI：
10.1038/srep18937
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发表时间：
2016-01-07
影响因子：
4.6
通讯作者：
Zhao Y
中科院分区：
文献类型：
--
作者：
Han H;Fan J;Xiong Y;Wu W;Lu Y;Zhang L;Zhao Y
基因 apterous (ap)、chip (chi) 和 beadex (bx) 在果蝇翼盘的背腹区划中发挥重要作用。同时，Notch 信号传导对于同一过程至关重要。据报道，Ap 和 Chi 作为四聚体调节 Notch 信号传导。同时，dLMO（bx基因的蛋白质产物）通过竞争Ap与Chi的结合来调节Ap的活性。然而，Chi和dLMO对Notch信号传导的详细功能和相关机制仍然知之甚少。在这里，我们报告了 Chi 和 dLMO 对 Notch 信号传导的详细功能。相邻细胞中不同的Chi蛋白水平可以激活Notch信号传导，主要是在Chi水平较高的细胞中。与 Chi 诱导的表型相比，dLMO 可以诱导 Notch 信号传导的拮抗表型。这些过程依赖于它们对边缘（fng）转录的直接调节。
Gene apterous (ap), chip (chi) and beadex (bx) play important roles in the dorsal-ventral compartmentalization in Drosophila wing discs. Meanwhile, Notch signaling is essential to the same process. It has been reported that Ap and Chi function as a tetramer to regulate Notch signaling. At the same time, dLMO (the protein product of gene bx) regulates the activity of Ap by competing its binding with Chi. However, the detailed functions of Chi and dLMO on Notch signaling and the relevant mechanisms remain largely unknown. Here, we report the detailed functions of Chi and dLMO on Notch signaling. Different Chi protein levels in adjacent cells could activate Notch signaling mainly in the cells with higher level of Chi. dLMO could induce antagonistical phenotypes on Notch signaling compared to that induced by Chi. These processes depend on their direct regulation of fringe (fng) transcription.