In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii
In vitro combined activity of amphotericin B, caspofungin and voriconazole against clinical isolates of Trichosporon asahii
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DOI：
10.1016/j.ijantimicag.2010.01.013
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发表时间：
2010-06-01
影响因子：
10.8
通讯作者：
Zhang, Jianzhong
中科院分区：
文献类型：
--
作者：
Li, Houmin;Lu, Qiaoyun;Zhang, Jianzhong
由阿萨希丝孢酵母引起的播散性感染很难解决。与协同药物的联合方案可以为治疗毛孢子菌病提供额外的选择。研究伏立康唑（VCZ）、卡泊芬净（CAS）和阿替霉素B（AMB）单独或联合应用对临床分离的嗜热厌氧菌的体外抗真菌活性。朝平。采用棋盘微量稀释法测定了VCZ、CAS和AMB对18株临床分离菌的联合抗菌活性。CAS与AMB的协同增效作用最高（89%），远高于AMB/VCZ和CAS/VCZ的协同增效作用（均为17%）。在任何情况下均未观察到拮抗作用。本研究表明，两种联合抗真菌药物，尤其是CAS和AMB的联合抗真菌活性高于CAS和AMB。Asahii比单独药物对该真菌更有效，这表明联合抗真菌治疗可能是治疗播散性毛孢子菌病的潜在策略。(C)2010年Elsevier B. V.和国际化疗学会。All rights reserved.
Disseminated infections caused by Trichosporon asahii are difficult to resolve. Combination regimens with synergistic drugs could provide additional options for treating trichosporonosis. The aim of this study was to evaluate the antifungal activities of voriconazole (VCZ), caspofungin (CAS) and amphotericin B (AMB) alone or in combination in vitro against clinical isolates of T. asahii. The combined antifungal activities of VCZ, CAS and AMB against 18 clinical isolates were assessed by a chequerboard microdilution method. CAS combined with AMB showed the highest percentage of synergistic effects (89%), much higher than those of the other two combinations (AMB/VCZ and CAS/VCZ both 17%). No antagonistic effect was observed in any case. This study demonstrates that the activity of two combined antifungals, especially the combination of CAS and AMB, against T. asahii is more effective than that of a drug alone against this fungus, suggesting that combined antifungal therapy may be a potential strategy for treating disseminated trichosporonosis. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.