Tissue-specific HIV-1 infection: why it matters.
Tissue-specific HIV-1 infection: why it matters.
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DOI：
10.2217/fvl.11.48
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发表时间：
2011-07
期刊：
影响因子：
3.1
通讯作者：
Smith DM
中科院分区：
文献类型：
--
作者：
Karris MA;Smith DM
人类免疫缺陷病毒对CD4+单核细胞表现出狭窄的趋向性，活化的CD4+T淋巴细胞是主要目标。当这些细胞因病毒复制、旁观者凋亡和免疫激活介导的细胞更新增加而耗尽时，就会出现进行性免疫缺陷（即艾滋病）。尽管有这种特定的细胞向性，艾滋病毒感染者几乎在每个器官系统中都表现出病理学。本文回顾了目前对中枢神经系统、生殖道和胃肠道相关淋巴组织中组织特异性 HIV-1 感染的认识。
The human immunodeficiency virus displays a narrow tropism for CD4+ mononuclear cells, and activated CD4+ T lymphocytes are the main target. When these cells are depleted by viral replication, bystander apoptosis and increased cell turnover mediated by immune activation, there is a progressive immunodeficiency (i.e., AIDS). Despite this specific cell tropism, HIV-infected persons demonstrate pathology in nearly every organ system. This article reviews current understanding of tissue-specific HIV-1 infection in the CNS, the genital tract, and gastrointestinal-associated lymphoid tissue.