The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma
The Diagnostic Capacity of Pre-treatment 18F-FDG PET/CT for Predicting the Extranodular Spread of Lymph Node Metastases in Patients with Oral Squamous Cell Carcinoma
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DOI：
10.18926/amo/58270
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发表时间：
2020-04-01
影响因子：
0.5
通讯作者：
Kanazawa, Susumu
中科院分区：
文献类型：
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作者：
Fukuhara, Ryuichiro;Shinya, Takayoshi;Kanazawa, Susumu
本研究的目的是评估预处理90分钟F-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-18-FDG PET/CT）预测口腔鳞状细胞癌淋巴结转移结节扩散的能力。我们回顾性分析了56例接受预治疗F-18-FDG PET/CT和颈淋巴结清扫术的患者的病例。测量了56个原发部位的最大标准化摄取值、代谢肿瘤体积和总病变糖酵解，并测量了115个淋巴结水平的最大标准化摄取值。7例患者的9个淋巴结水平存在结外扩散。原发灶代谢性肿瘤体积、糖酵解总量及淋巴结最大标准摄取值在有无结节扩散组间差异有统计学意义（P < 0.05）。结合原发部位总病变糖酵解和淋巴结最大标准化摄取体积在各自的最佳截止值，预测结节扩散的敏感性，特异性和准确性分别为89%，92%和92%。治疗前F-18-FDG PET/CT可用于预测口腔鳞状细胞癌患者的结节扩散。联合使用原发部位总病变糖酵解和淋巴结最大标准化摄取值比单独使用任一预测值显示出更大的预测价值。
The aim of this study was to evaluate the ability of pretreatment 90-min F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) to predict the extranodular spread of lymph node metastases in oral squamous cell carcinoma. We retrospectively reviewed the cases of 56 patients who underwent pretreatment F-18-FDG PET/CT and surgery with neck dissection. Maximum standardized uptake value, metabolic tumor volume, and total lesion glycolysis were measured for the 56 primary sites and maximum standardized uptake value was measured for 115 lymph node levels. Extranodular spread was present at 9 lymph node levels in 7 patients. Significant differences were found in metabolic tumor volume and total lesion glycolysis of the primary site, and in lymph node maximum standardized uptake value, between patients with and without extranodular spread (p < 0.05). Combining primary site total lesion glycolysis and lymph node maximum standardized uptake volume at their respective optimal cutoffs, the sensitivity, specificity, and accuracy for predicting extranodular spread were 89%, 92%, and 92%, respectively. Pretreatment F-18-FDG PET/CT is useful for predicting extranodular spread in patients with oral squamous cell carcinoma. The combined use of primary site total lesion glycolysis and lymph node maximum standardized uptake value showed greater predictive value than either predictor singly.