Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease
Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease
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DOI：
10.1136/gut.2008.167957
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发表时间：
2009-08-01
期刊：
影响因子：
24.5
通讯作者：
Panes, J.
中科院分区：
文献类型：
--
作者：
Rimola, J.;Rodriguez, S.;Panes, J.
目的：评估克罗恩病的病情范围和活动性对指导治疗至关重要。目前的横断面研究的目的是确定MR的准确性，为这个assessment.Design：50例临床活动（n = 35）或非活动（n = 15）克罗恩病进行回结肠镜检查（参考标准）和MR。T2加权和precontrast和postcontrast增强T1加权序列被收购。采用CDEIS（克罗恩病内镜严重程度指数）评价内镜活动性;此外，将内镜病变分为无、轻度（无溃疡的炎症）或重度（存在溃疡）。结果：无、轻度和重度炎症肠段的比较显示进行性和显著性（P < 0.05）。
Objective: Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment.Design: 50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolonoscopy (reference standard) and MR. T2-weighted and precontrast and postcontrast-enhanced T1-weighted sequences were acquired. Endoscopic activity was evaluated by CDEIS (Crohn's Disease Endoscopic Index of Severity); in addition endoscopic lesions were classified as absent, mild (inflammation without ulcers) or severe (presence of ulceration).Results: The comparison of intestinal segments with absent, mild and severe inflammation demonstrated a progressive and significant (p