Evidence for biliary excretion of vancomycin into stool during intravenous therapy: Potential implications for rectal colonization with vancomycin-resistant enterococci
Evidence for biliary excretion of vancomycin into stool during intravenous therapy: Potential implications for rectal colonization with vancomycin-resistant enterococci
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DOI：
10.1128/aac.48.11.4427-4429.2004
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发表时间：
2004-11-01
影响因子：
4.9
通讯作者：
Lemos, L
中科院分区：
文献类型：
--
作者：
Currie, BP;Lemos, L
从33例接受静脉万古霉素治疗的患者中前瞻性收集了63份粪便样本和5份胆汁样本，并通过竞争性免疫测定法定量分析万古霉素。万古霉素每12小时1 g，治疗≥ 5天后，几乎所有患者均通过胆汁排泄至粪便中，浓度为3.3 - 94.8 μ g/ml。
Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 mug/ml after greater than or equal to 5 days of a therapy of 1 g every 12 h.