Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors.
Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors.
复制标题
化学药物：新型10位取代金雀花碱衍生物，对α4β2烟碱乙酰胆碱受体具有更高的选择性。
DOI：
10.1002/cmdc.200700073
复制
发表时间：
2007
期刊：
影响因子：
3.4
通讯作者：
Petukhov,PavelA
中科院分区：
文献类型：
--
作者：
Kozikowski,AlanP;Chellappan,SheelaK;Xiao,Yingxian;Bajjuri,KrishnaMohan;Yuan,Hongbin;Kellar,KennethJ;Petukhov,PavelA
Neuronal nicotinic acetylcholine receptors are widely distributed in the central and peripheral nervous systems. Several lines of evidence suggest that the α4β2 nAChRs mediate addiction to nicotine in tobacco smoking. Novel 10-substituted cytisine derivatives with increased selectivity for α4β2 nicotinic acetylcholine receptors were synthesized and may be of use in smoking cessation.(Chemical Equation Presented).© 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
