CIRCADIAN CORTICOSTEROID PERIODICITY - CRITICAL PERIOD FOR ABOLITION BY NEONATAL INJECTION OF CORTICOSTEROID
CIRCADIAN CORTICOSTEROID PERIODICITY - CRITICAL PERIOD FOR ABOLITION BY NEONATAL INJECTION OF CORTICOSTEROID
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DOI：
10.1126/science.178.4066.1205
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发表时间：
1972-01-01
期刊：
影响因子：
56.9
通讯作者：
KRIEGER, DT
中科院分区：
文献类型：
--
作者：
KRIEGER, DT
大鼠血浆中皮质类固醇浓度的昼夜变化如果在新生儿生命的第2天至第4天给予皮质类固醇，但如果在新生儿生命的第12天至第14天给予皮质类固醇，则不会受到抑制。这表明皮质类固醇对调节这种周期性的中枢神经系统通路影响的关键时期。皮质类固醇的昼夜周期不受新生儿睾酮或利血平的影响。
Circadian variation of corticosteroid concentrations in rat plasma is suppressed if corticosteroids are administered between days 2 to 4 of neonatal life, but not if they are given between days 12 to 14 of neonatal life. This indicates a critical period for the effect of corticosteroid administration on the central nervous system pathways regulating such periodicity. Circadian periodicity of corticosteroids is not affected by neonatal administration of testosterone or reserpine.