Bioactive lysolipids in cancer and angiogenesis.
Bioactive lysolipids in cancer and angiogenesis.
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DOI：
10.1016/j.pharmthera.2018.07.006
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发表时间：
2019-01
影响因子：
13.5
通讯作者：
Hla T
中科院分区：
文献类型：
--
作者：
Hisano Y;Hla T
虽然正常的血管生成对发育和组织生长至关重要，但病理性血管生成通过提供营养和氧气以及为远处转移提供管道，对癌症的生长和扩散非常重要。细胞外基质分子、肿瘤细胞、内皮细胞、成纤维细胞和免疫细胞之间的相互作用是病理性血管生成的关键，这些细胞产生的各种血管生成因子、趋化因子和脂质介质以及低氧微环境通过调节各种相关基因的表达和/或活性来促进血管生成。1-磷酸鞘氨醇和溶血磷脂酸是通过G蛋白偶联受体发挥作用的生物活性脂质介质，在血管生成中起关键作用。此外，其他脂质介质包括前列腺素E2、脂氧素和溶血素是以刺激依赖的方式产生的，并具有促进或抑制血管生成的作用，可能是通过它们特定的GPCR。在某些肿瘤组织中观察到脂质介质信号转导通路的失调。这篇综述将集中于LPA和S1P，这两种生物活性脂质介质在调节血管生成和细胞迁移方面发挥着重要作用，而血管生成和细胞迁移是肿瘤生长和扩散的关键。
While normal angiogenesis is critical for development and tissue growth, pathological angiogenesis is important for the growth and spread of cancers by supplying nutrients and oxygen as well as providing a conduit for distant metastasis. The interaction among extracellular matrix molecules, tumor cells, endothelial cells, fibroblasts, and immune cells is critical in pathological angiogenesis, in which various angiogenic growth factors, chemokines, and lipid mediators produced from these cells as well as hypoxic microenvironment promote angiogenesis by regulating expression and/or activity of various related genes. Sphingosine 1-phosphate and lysophosphatidic acid, bioactive lipid mediators which act via specific G protein-coupled receptors, play critical roles in angiogenesis. In addition, other lipid mediators including prostaglandin E2, lipoxin, and resolvins are produced in a stimulus-dependent manner and have pro- or anti-angiogenic effects, presumably through their specific GPCRs. Dysregulated lipid mediator signaling pathways are observed in the contxt of some tumors. This review will focus on LPA and S1P, two bioactive lipid mediators in their regulation of angiogenesis and cell migration that are critical for tumor growth and spread.
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DOI：
10.1016/j.prostaglandins.2004.12.001
发表时间：
2005-05-01
影响因子：
2.9
作者：
Chang, SH;Liu, CH;Hla, T
通讯作者：
Hla, T
影响因子：
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4.8
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通讯作者：
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影响因子：
15.9
作者：
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通讯作者：
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