Free electron laser ablation of urinary calculi: An experimental study
Free electron laser ablation of urinary calculi: An experimental study
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DOI：
10.1109/2944.983308
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发表时间：
2001-11-01
影响因子：
4.9
通讯作者：
Jansen, ED
中科院分区：
文献类型：
--
作者：
Chan, KF;Choi, B;Jansen, ED
研究了红外激光消融泌尿系结石随波长的变化，以确定消融阈值注量、消融深度和光学吸收之间的关系。采用简单的光热消融模型来检验这种关系。使用了由 >95% 尿酸、>95% 胱氨酸、>95% 一水草酸钙 (CONI) 和 >90% 六水磷酸镁铵 (MAPH) 组成的人类尿路结石。 2.1 至 6.5 µm 之间的各种波长。选择执行阈值注量和消融深度测量。本研究的激光源是范德比尔特大学的可调谐脉冲红外自由电子激光器 (FEL)。实验结果表明阈值注量和烧蚀深度与结石的光学吸收特性之间存在相关性。当微积分光吸收增加时，阈值通量降低。尽管烧蚀深度随着结石光学吸收而增加，但结果表明，在某些结石中，烧蚀深度受到烧蚀羽流的光学衰减的影响。这些观察结果与光热消融模型一致，但较高光学吸收下条纹状结石的断裂表明了光机械机制的贡献。
Infrared laser ablation of urinary calculi was investigated as a function of wavelength to determine the relation of ablation threshold fluences, ablation depths, and optical absorption. A simple photothermal ablation model was employed to examine this relationship.Human urinary calculi composed of >95% uric acid, >95% cystine, >95% calcium oxalate monohydrate (CONI), and >90% magnesium ammonium phosphate hexahydrate (MAPH) were used. Various wavelengths between 2.1 and 6.5 mum. were selected to perform threshold fluence and ablation depth measurements. The laser source for this study was the tunable pulsed infrared free electron laser (FEL) at Vanderbilt University.Experimental results indicated a correlation of threshold fluence and ablation depth to the optical absorption properties of the calculi. When calculus optical absorption increased, the threshold fluences decreased. Although the ablation depths increased with calculus optical absorption, results indicated that in certain calculi the ablation depth was affected by optical attenuation through the ablation plume. These observations were in agreement with the photothermal ablation model, but fractures in striated calculi at higher optical absorptions indicated the contribution of a photomechanical mechanism.