Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.
Impact of treatment duration and lesion size on effectiveness of chondroitinase treatment post-SCI.
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DOI：
10.1016/j.expneurol.2015.02.028
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发表时间：
2015-05
影响因子：
5.3
通讯作者：
Howland DR
中科院分区：
文献类型：
--
作者：
Mondello SE;Jefferson SC;Tester NJ;Howland DR
The effects of 2 weeks of intralesional chondroitinase abc (ch'abc) treatment on anatomical plasticity and behavioral recovery are examined in adult cats and compared to results achieved with 4 weeks of treatment following tightly controlled lateral hemisection injuries. Analyses also were completed using 35 cats with a range of hemisection magnitudes to assess relationships between treatment duration, lesion size and functional recovery. Results indicate that both 2 and 4 weeks of treatment significantly increased the number of rubrospinal tract (RuST) neurons with axons below the lesion, but neither affected the number of corticospinal tract neurons. Similarly, both treatment periods also accelerated recovery of select motor tasks, which carries considerable importance with respect to human health care and rehabilitation. Four weeks of treatment promoted recovery beyond that seen with 2 weeks in its significant impact on accuracy of movement critical for placement of the ipsilateral hindlimb onto small support surfaces during the most challenging locomotor tasks. Analyses, which extended to a larger group of cats with a range of lesion magnitudes, indicate that 4 weeks of ch'abc treatment promoted earlier recovery as well as significantly greater targeting accuracy even in cats with larger lesions. Together, these results support the potential for ch'abc to promote anatomical and behavioral recovery and suggest that intraspinal treatment with ch'abc continues to enhance motor recovery and performance beyond the subacute injury period and diminishes the impact of lesion size.
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影响因子：
3.8
作者：
EIDELBERG, E;NGUYEN, LH;DEZA, LD
通讯作者：
DEZA, LD
影响因子：
5.3
作者：
Houle, John D.;Tom, Veronica J.;Silver, Jerry
通讯作者：
Silver, Jerry
影响因子：
8.8
作者：
Creeley CE;Dikranian KT;Dissen GA;Back SA;Olney JW;Brambrink AM
通讯作者：
Brambrink AM
软骨素酶ABC促进脊髓损伤后完整和受伤的脊柱系统的发芽。
DOI：
10.1523/jneurosci.2980-06.2006
发表时间：
2006-10-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Barritt AW;Davies M;Marchand F;Hartley R;Grist J;Yip P;McMahon SB;Bradbury EJ
通讯作者：
Bradbury EJ
影响因子：
2.5
作者：
Beloozerova, Irina N.;Farrell, Bradley J.;Prilutsky, Boris I.
通讯作者：
Prilutsky, Boris I.