Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators
Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators
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见血封喉中的强心内酯作为有效的选择性 Nur77 调节剂
DOI：
10.1248/cpb.56.1005
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发表时间：
2008-07-01
影响因子：
1.7
通讯作者：
Yao, Xin-Sheng
中科院分区：
文献类型：
--
作者：
Jiang, Miao-Miao;Dai, Yi;Yao, Xin-Sheng
毒毛旋花子苷D（1）是一种新的强心苷，通过生物活性导向分离法从见血封喉（Antiaris toxicaria LESCH.）的茎中与其他10种已知化合物一同被分离出来。它们的结构通过光谱分析得以确定。所有报道的化合物在纳摩尔浓度下均能有效抑制多种癌细胞系的生长。癌细胞生长的抑制伴随着类固醇/甲状腺激素受体超家族中一种强效促凋亡成员Nur77表达的诱导。
Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.