The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection.
The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection.
复制标题
DOI：
10.1155/2012/134645
复制
发表时间：
2012-01-01
影响因子：
2.2
通讯作者：
McDowell, Mary Ann
中科院分区：
文献类型：
--
作者：
Whitcomb, James P;Deagostino, Mary;McDowell, Mary Ann
维生素D信号调节各种免疫反应。在这里，我们评估了维生素D在维生素D受体缺陷小鼠（VDRKO）实验性利什曼病感染免疫中的作用。我们观察到，与野生型（WT）小鼠相比，遗传耐药背景下的VDRKO小鼠减少了主要利什曼原虫诱导的病变发展;此外，感染真皮中的寄生虫负荷在感染高峰时显著降低。活性形式维生素D的酶促消耗模拟VDR的消融，导致对L.少校相反，VDRKO或维生素D缺乏小鼠在易感性Th 2偏置背景下的易感性没有变化。这些研究表明，维生素D缺乏，无论是通过消除VDR或消除其配体，1，25 D3，导致增加抵抗L。严重感染，但仅在易受Th-1免疫应答的宿主中。
Vitamin D signaling modulates a variety of immune responses. Here, we assessed the role of vitamin D in immunity to experimental leishmaniasis infection in vitamin D receptor-deficient mice (VDRKO). We observed that VDRKO mice on a genetically resistant background have decreased Leishmania major-induced lesion development compared to wild-type (WT) mice; additionally, parasite loads in infected dermis were significantly lower at the height of infection. Enzymatic depletion of the active form of vitamin D mimics the ablation of VDR resulting in an increased resistance to L. major. Conversely, VDRKO or vitamin D-deficient mice on the susceptible Th2-biased background had no change in susceptibility. These studies indicate vitamin D deficiency, either through the ablation of VDR or elimination of its ligand, 1,25D3, leads to an increase resistance to L. major infection but only in a host that is predisposed for Th-1 immune responses.