Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2.
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发表时间：
1986
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影响因子：
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通讯作者：
A C Webb;K. Collins;P. Auron;R. Eddy;H. Nakai;M. Byers;L. Haley;W. Henry;Shows Tb
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文献类型：
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作者：
A C Webb;K. Collins;P. Auron;R. Eddy;H. Nakai;M. Byers;L. Haley;W. Henry;Shows Tb
用人单核细胞衍生的白细胞介素1(IL1)的优势(PI7)互补DNA(CDNAs)探针和30个人-鼠体细胞杂交种，用限制性内切酶BglII对杂交体细胞DNA进行Southern印迹分析，将IL1基因定位于人2号染色体。通过与人中期染色体的原位杂交，将IL1基因定位于2号染色体长臂的2q13-2q21两个脆性位点之间。
A complementary DNA (cDNA) probe for the predominant (pI 7) form of human monocyte-derived interleukin-1 (IL1) and a collection of 30 human-mouse somatic cell hybrids were used to assign the IL1 gene to human chromosome 2 by Southern blot analysis of hybrid cell DNA digested with the restriction endonuclease BglII. In situ hybridization to human metaphase chromosomes localized the IL1 gene to the long arm of chromosome 2 at position 2q13-2q21 between two fragile sites.