Intra-articular injectable hydroxypropyl chitin/hyaluronic acid hydrogel as bio-lubricant to attenuate osteoarthritis progression
Intra-articular injectable hydroxypropyl chitin/hyaluronic acid hydrogel as bio-lubricant to attenuate osteoarthritis progression
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DOI：
10.1016/j.matdes.2022.110579
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发表时间：
2022-04-05
影响因子：
8.4
通讯作者：
Xiao, Jun
中科院分区：
文献类型：
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作者：
Liu, Wenbin;Ma, Mengsi;Xiao, Jun
骨关节炎是一种慢性退行性关节疾病，其进展的主要标志是关节摩擦力的显著增加和关节软骨的破坏。联合软骨修复和关节润滑可能是治疗骨关节炎的可行策略。本研究将羟丙基甲壳素（HPCH）与透明质酸（HA）物理混合制备成HPCH/HA水凝胶，作为一种新型的生物润滑剂和软骨保护剂用于骨关节炎的治疗。HPCH/HA水凝胶的HA释放更加持久和稳定，体外实验表明HPCH/HA水凝胶可以促进软骨细胞合成细胞外基质。此外，HPCH/ HA水凝胶可延缓DMM诱导的骨关节炎小鼠模型的骨关节炎进展。综上所述，本发明所开发的HPCH/HA水凝胶可实现关节良好润滑和软骨保护的双重功能，具有协同治疗骨关节炎的临床潜力。2022作者由爱思唯尔有限公司出版。这是一篇在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Osteoarthritis is a chronic degenerative joint disease and its signs of progress mainly attribute to the significant increase of joint friction and the destruction of articular cartilage. Combined cartilage repair and joint lubrication may be a feasible strategy for the treatment of osteoarthritis. In this study, the hydroxypropyl chitin (HPCH)/hyaluronic acid (HA) hydrogel, prepared by physical mixing of HA and HPCH, was designed to be a new bio-lubricant and a chondroprotective agent for osteoarthritis treatment. HA release in HPCH/HA hydrogel was more durable and stable and in vitro experiments showed that HPCH/HA hydrogel could promote the synthesis of the extracellular matrix of chondrocytes. Additionally, HPCH/ HA hydrogel could delay the progression of osteoarthritis in DMM-induced osteoarthritis mouse model. To sum up, HPCH/HA hydrogel developed herein can achieve the dual function of well lubrication of joints and protection of cartilage and has the clinical potential as synergetic treatment of osteoarthritis. CO 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).