Interleukin-17 and airway remodelling
Interleukin-17 and airway remodelling
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DOI：
10.1016/j.pupt.2005.02.004
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Lindén, A
中科院分区：
文献类型：
--
作者：
Lindén, A
白细胞介素（IL）-17 A通过协调持续的嗜中性粒细胞动员而在增强先天免疫中起重要作用。尽管有迹象表明IL-17 A与特定的气道疾病有关，但仍然没有最终证据表明IL-17 A发挥真正的致病作用。在小鼠中有证据表明内源性IL-17 A有助于过敏原诱导的气道高反应性的发展，并且也有证据表明IL-17 A刺激具有已知气道重塑能力的几种细胞因子从通常驻留在气道中的细胞中释放。需要新的研究来确定这些对局部细胞的影响是否真的有助于体内气道重塑。如果是这种情况，那么IL-17 A可能构成过敏性气道疾病药物干预的有用靶点。(c)2005爱思唯尔有限公司保留所有权利。
Interleukin (IL)-17A is emerging as important in reinforcing innate immunity by orchestrating sustained neutrophilic mobilisation. Even though there are indications of association with specific airway diseases, there is still no final proof that IL-17A plays a truly causative pathogenic role. There is evidence in mice that endogenous IL-17A contributes to the development of allergen-induced airway hyperresponsiveness and there is also evidence that IL-17A stimulates the release of several cytokines with known capacity for airway remodelling, from cells normally residing in the airways. New studies are required to determine whether these effects-on local cells actually contribute to airway remodelling in vivo. If this is the case, then IL-17A may constitute a useful target for pharmacotherapeutic intervention in allergic airway disease. (c) 2005 Elsevier Ltd. All rights reserved.