Plasma miR-124 as a biomarker for cerebral infarction
Plasma miR-124 as a biomarker for cerebral infarction
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DOI：
10.2220/biomedres.32.135
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发表时间：
2011-04-01
影响因子：
1.2
通讯作者：
Iwai, Naoharu
中科院分区：
文献类型：
--
作者：
Weng, Huachun;Shen, Chunshen;Iwai, Naoharu
MicroRNAs(MiRNAs)是一种内源性小RNA，通过下调靶基因在多种生理过程中发挥重要作用。近年来，血浆miRNAs被认为是多种疾病的生物标志物。在本研究中，对不同组织的miRNA阵列分析表明，miR-124几乎只在中枢神经系统和神经细胞中表达，这表明它可能是一种潜在的神经系统疾病的生物标志物。我们研究了脑特定miRNA的血浆浓度是否可以作为脑梗塞的生物标志物，在大鼠大脑中动脉闭塞(MCAO)的脑梗塞模型中。MCAO后6h，miR-124血浆浓度显著升高，48h后仍维持在较高水平。因此，miR-124的血浆浓度为脑梗塞的早期发现提供了一个有希望的候选生物标志物。
MicroRNAs (miRNAs) are endogenous small RNAs that play an important role in various physiological processes by downregulating target genes. Recently, plasma miRNAs have been investigated as biomarkers for various diseases. In this study, miRNA array analysis in various tissues showed that miR-124 is almost exclusively expressed in the central nervous system and neuronal cells, suggesting that it might be useful as a potential biomarker for neurological diseases. We examined whether plasma concentrations of brain-specific miRNA can serve as a biomarker for cerebral infarction, where the cerebral infarction was modeled by middle cerebral artery occlusion (MCAO) in the rat. Plasma concentrations of miR-124 were significantly elevated at 6 h, and remained elevated at 48 h after MCAO introduction. Thus, plasma concentration of miR-124 provides a promising candidate biomarker for early detection of cerebral infarction.