Effects of macrocyclic polyamines and polymethylenediamines on reactions influenced by polyamines.
Effects of macrocyclic polyamines and polymethylenediamines on reactions influenced by polyamines.
复制标题
大环多胺和聚亚甲基二胺对受多胺影响的反应的影响。
DOI：
10.1016/0304-4165(80)90203-2
复制
发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Eiichi Kimura
中科院分区：
文献类型：
--
作者：
K. Igarashi;Keiko Kashiwagi;Tomohito Kakegawa;Seiyu Hirose;T. Yatsunami;Eiichi Kimura
研究了大环多胺和多亚甲基二胺对多胺影响的各种反应的影响。其中2，3，4，3-和3，3，3，4-环多胺、NH_2（CH_2）_6NH_2和NH_2（CH_2）_8NH_2对多苯丙氨酸合成、珠蛋白合成和大鼠肝脏异亮氨酰-tRNA的形成有一定的刺激作用。刺激的程度是最多40%的多胺所获得的。在牛胰腺RNA酶A降解聚（C），所有测试的胺刺激降解。在NADPH依赖的大鼠肝微粒体脂质过氧化反应中，2，3，2，3-或2，3，3，3-环多胺的抑制程度大于精胺。2，3，4，3-和3，3，3，4-环多胺、NH_2（CH_2）_（10）NH_2和精胺对寡霉素敏感的ATP酶水解ATP的抑制程度相当。大环多胺或多亚甲基二胺都不能刺激需要多胺的大肠杆菌突变体的生长。胺对各种反应的影响的差异可能的解释进行了讨论。
The effects of macrocyclic polyamines and polymethylenediamines on various reactions influenced by polyamines have been studied. Among the amines tested, 2,3,4,3- and 3,3,3,4-cyclic polyamines, NH2(CH2)6NH2and NH2(CH2)8NH2had some ability to stimulate polyphenylalanine synthesis, globin synthesis and rat liver isoleucyl-tRNA formation. The degree of stimulation was at most 40% of that obtained by polyamines. In the degradation of poly(C) by bovine pancreatic RNAase A, all tested amines stimulated the degradation. In the NADPH-dependent lipid peroxidation of rat liver microsomes, the degree of inhibition by 2,3,2,3- or 2,3,3,3-cyclic polyamine was greater than that by spermine. The hydrolysis of ATP by an oligomycin-sensitive ATPase was inhibited by 2,3,4,3- and 3,3,3,4-cyclic polyamines, NH2(CH2)10NH2and spermine at somewhat comparable levels. None of the macrocyclic polyamines or polymethylenediamines stimulated the growth of a polyamine-requiring mutant ofEscherichia coli. Possible explanations for the differences in the effects of amines on the various reactions are discussed.