Reproductive biology of female Bmal1 null mice
Reproductive biology of female Bmal1 null mice
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DOI：
10.1530/rep-09-0523
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发表时间：
2010-06-01
期刊：
影响因子：
3.8
通讯作者：
Kennaway, David J.
中科院分区：
文献类型：
--
作者：
Boden, Michael J.;Varcoe, Tamara J.;Kennaway, David J.
已知光/暗周期和视交叉上核节律性对啮齿动物的生殖功能有重要影响。我们研究了雌性杂合和纯合脑和肌肉ARNT样蛋白1（Bmal 1，也称为Arntl）缺失小鼠的生殖功能，这些小鼠缺乏中枢和外周细胞节律。杂合子Bmal 1小鼠发育正常，具有生育能力，具有明显的正常妊娠进展和窝仔数，但断奶前的产后死亡率较高（1.1-1.3/窝）。基因型分布呈偏态，杂合子和无效基因型均未被充分代表（1.0：1.7：0.7; P
The light/dark cycle and suprachiasmatic nucleus rhythmicity are known to have important influences on reproductive function of rodents. We studied reproductive function in female heterozygous and homozygous brain and muscle ARNT-like protein 1 (Bmal1, also known as Arntl) null mice, which lack central and peripheral cellular rhythms. Heterozygous Bmal1 mice developed normally and were fertile, with apparent normal pregnancy progression and litter size, although postnatal mortality up to weaning was high (1.1-1.3/litter). The genotype distribution was skewed with both heterozygous and null genotypes underrepresented (1.0:1.7:0.7; P