Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment
Cardiorespiratory Fitness and White Matter Neuronal Fiber Integrity in Mild Cognitive Impairment
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DOI：
10.3233/jad-170415
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发表时间：
2018-01-01
影响因子：
4
通讯作者：
Zhang, Rong
中科院分区：
文献类型：
--
作者：
Ding, Kan;Tarumi, Takashi;Zhang, Rong
背景资料：越来越多的证据表明，自我报告的体力活动水平与正常成人和轻度认知障碍（MCI）患者的白色物质（WM）完整性和认知能力呈正相关。目的：探讨老年MCI患者最大摄氧量（VO（2）max）测定的心肺功能（CRF）与WM纤维完整性和神经认知功能的关系。方法：81名参与者（年龄= 65 +/- 7岁，43名女性），包括26名认知正常的老年人和55名遗忘型MCI患者，接受VO 2 max测试以测量CRF，弥散张量成像（DTI）评估WM纤维的完整性，神经认知评估集中在记忆和执行功能。结果：认知功能正常的老年人和MCI患者在整体WM纤维完整性和VO（2）max方面没有差异。VO（2）max与54%的WM纤维束的各向异性分数的DTI指标呈正相关，与46%和56%的WM纤维束的平均和径向扩散率呈负相关。在校正年龄、性别、体重指数、WM病变负荷和MCI状态后，VO 2 max与DTI指标的相关性仍具有统计学意义。从与VO（2）max相关的区域获得的DTI指标与MCI患者的执行功能表现相关。结论：高水平的CRF与更好的WM纤维完整性相关，而更好的WM纤维完整性又与MCI患者更好的执行功能表现相关。
Background: Mounting evidence showed the self-reported levels of physical activity are positively associated with white matter (WM) integrity and cognitive performance in normal adults and patients with mild cognitive impairment (MCI). However, the objective measure of cardiorespiratory fitness (CRF) was not used in these studies.Objective: To determine the associations of CRF measured by maximal oxygen uptake (VO(2)max) with WM fiber integrity and neurocognitive performance in older adults with MCI.Methods: Eighty-one participants (age = 65 +/- 7 years, 43 women), including 26 cognitively normal older adults and 55 amnestic MCI patients, underwent VO2max test to measure CRF, diffusion tensor imaging (DTI) to assessWMfiber integrity, and neurocognitive assessment focused on memory and executive function. DTI data were analyzed by the tract-based spatial statistics and region-of-interest approach.Results: Cognitively normal older adults and MCI patients were not different in global WM fiber integrity and VO(2)max. VO(2)max was associated positively with DTI metrics of fractional anisotropy in similar to 54% WM fiber tracts, and negatively with mean and radial diffusivities in similar to 46% and similar to 56% of the WM fiber tracts. The associations of VO(2)max with DTI metrics remained statistically significant after adjustment of age, sex, body mass index, WM lesion burden, and MCI status. The DTI metrics obtained from the area that correlated to VO(2)max were associated with executive function performance in MCI patients.Conclusions: Higher levels of CRF are associated with better WM fiber integrity, which in turn is correlated with better executive function performance in MCI patients.