A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia
A failure of sleep-dependent procedural learning in chronic, medicated schizophrenia
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DOI：
10.1016/j.biopsych.2004.09.012
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发表时间：
2004-12-15
影响因子：
10.6
通讯作者：
Stickgold, R
中科院分区：
文献类型：
--
作者：
Manoach, DS;Cain, MS;Stickgold, R
背景：精神分裂症患者很难研究证明精神分裂症患者的程序性学习完整，最近的研究结果表明程序性学习的一个关键组成部分依赖于睡眠。这项研究检验了精神分裂症患者在依赖睡眠的程序性学习方面存在缺陷的假设。方法：使用简单、特征明确的运动技能学习测试，即手指敲击运动序列任务 (MST)，对 26 名慢性药物精神分裂症患者和 14 名人口统计匹配的健康对照受试者进行了两次测试，每次测试间隔 24 小时。主要结果指标是第一天的 MST 学习（依赖于实践的学习）和夜间依赖于睡眠的改善表现。结果：尽管精神分裂症患者和对照受试者在依赖于实践的学习方面没有差异，但患者未能表现出夜间改善（恶化 4%），并且与对照受试者显着不同，对照受试者显示出显着的 11% 改善。结论：我们在这里首次展示了慢性药物治疗中依赖睡眠的程序性学习巩固失败的情况。精神分裂症。这种缺陷发生在培训课程中正常的依赖于实践的学习的背景下。这种行为分离与练习和睡眠依赖性运动学习反映独立过程的证据一致，并表明它们在精神分裂症中受到不同的影响。
Background: Schizophrenia patients have difficulty studies demonstrate intact procedural learning in schizophrenia, recent findings demonstrate that a critical component of procedural learning is dependent on sleep. This study tested the hypothesis that patients with schizophrenia have a deficit in sleep-dependent procedural learning.Methods: Using a simple, well-characterized test of motor skill learning, the finger tapping motor sequence task (MST), 26 patients with chronic, medicated schizophrenia and 14 demographically matched healthy control subjects were tested on two occasions, 24 hours apart. The main outcome measures were learning of the MST on day 1 (practice-dependent learning) and overnight, sleep-dependent improvement performance.Results: Although schizophrenia patients and control subjects did not differ,fer in practice-dependent learning, patients failed to show overnight improvement (4% deterioration) and differed significantly from control subjects who showed a significant 11% improvement.Conclusions: We present here the first demonstration of a failure of sleep-dependent consolidation of procedural learning in chronic, medicated schizophrenia. This deficit occurred in the context of normal practice-dependent learning within a training session. This behavioral dissociation is consistent with evidence that practice- and sleep-dependent motor learning reflect independent processes and suggests that they are differentially affected in schizophrenia.