Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure
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DOI：
10.1161/01.res.0000031151.21145.59
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发表时间：
2002-08-23
影响因子：
20.1
通讯作者：
Sabbah, HN
中科院分区：
文献类型：
--
作者：
Chandler, MP;Stanley, WC;Sabbah, HN
本研究评估雷诺嗪是否在不增加心肌耗氧量的情况下增加心力衰竭（HF）犬的左心室（LV）功能（M（V）over dot o（2）），从而改善LV机械效率。雷诺嗪并没有改变M（V）超过dot O-2，左心室机械效率增加（22.4+/-2.8%至30.9+/-3.4%（P
The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (M(V) over dot o(2)) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change M(V) over dot O-2 and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P