INVOLVEMENT OF P34CDC2 IN ESTABLISHING THE DEPENDENCY OF S-PHASE ON MITOSIS
INVOLVEMENT OF P34CDC2 IN ESTABLISHING THE DEPENDENCY OF S-PHASE ON MITOSIS
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DOI：
10.1038/349388a0
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发表时间：
1991-01-31
期刊：
影响因子：
64.8
通讯作者：
NURSE, P
中科院分区：
文献类型：
--
作者：
BROEK, D;BARTLETT, R;NURSE, P
Cd~(2+)的突变体可以破坏S期对前一次有丝分裂完成的依赖。通过改变p34cdc2的状态，有可能将细胞从进入有丝分裂期重新编程到经历S期。这导致了一种建议，即细胞周期可以被认为是p34cdc2周期，并对生命周期的进化具有意义。
Mutants of cdc2+ can disrupt the dependency of S phase on completion of the previous mitosis. By changing the state of p34cdc2 it is possible to reprogramme a cell from entering mitosis to undergoing S phase. This leads to the proposal that the cell cycle can be considered a p34cdc2 cycle, and has implications for the evolution of life cycles.