Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR)
Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR)
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DOI：
10.1016/s0730-725x(02)00469-1
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发表时间：
2002-02-01
影响因子：
2.5
通讯作者：
Lou, HC
中科院分区：
文献类型：
--
作者：
Born, AP;Rostrup, E;Lou, HC
睡眠和镇静的儿童可以对视觉刺激作出反应，降低血氧水平依赖（BOLD）功能性MRI信号反应。代谢和血液动力学参数对这种逆信号响应的贡献还不完全清楚。据推测，这是由于与rCBF（局部脑血流量）增加相比，耗氧量增加相对较大所致。我们在1.5T磁共振扫描仪上用动脉水自旋标记技术（FAIR）和BOLD功能磁共振成像研究了4名4-71个月的镇静儿童和4名清醒成人在视觉刺激过程中的rCBF变化。在儿童中，FAIR信号平均下降了0.96%（范围0.77-1.05）的非选择性图像的基线期，而BOLD信号下降了2.03%（范围1.99-2.93）。在成人中，FAIR和BOLD信号分别增加0.88%（范围0.8-0.99）和2.63%（范围1.99-2.93）。因此，在儿童中，灌注MRI不能检测到rCBF增加，但FAIR信号减少的迹象被发现。在刺激过程中初级视皮层的rCBF减少以前没有报道过，但它是负BOLD反应的一个可能的解释。未来的研究将必须解决这种反应模式是否是年龄或睡眠/镇静的结果。(C)2002年爱思唯尔科技有限公司All rights reserved.
Sleeping and sedated children can respond to visual stimulation with a decrease in blood oxygenation level dependent (BOLD) functional MRI signal response. The contribution of metabolic and hemodynamic parameters to this inverse signal response is incompletely understood. It has been hypothesized that it is caused by a relatively greater increase of oxygen consumption compared to rCBF (regional cerebral blood flow) increase. We studied the rCBF changes during visual stimulation in four sedated children, aged 4-71 months, and four alert adults, with an arterial water spin labeling technique (FAIR) and BOLD fMRI in a 1.5T MR scanner. In the children, FAIR signal decreased by a mean of 0.96% (range 0.77-1.05) of the baseline periods of the non-selective images, while BOLD signal decreased by 2.03% (range 1.99-2.93). In the adults, FAIR and BOLD signal increased by 0.88% (range 0.8-0.99) and 2.63% (range 1.99-2.93), respectively. Thus, in the children, an rCBF increase could not be detected by perfusion MRI, but indications of a FAIR signal decrease were found. An rCBF decrease in the primary visual cortex during stimulation has not been reported previously, but it is a possible explanation for the negative BOLD response. Future studies will have to address if this response pattern is a consequence of age or sleep/sedation. (C) 2002 Elsevier Science Inc. All rights reserved.