Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats.
Hippocampal theta rhythm and the firing of neurons in walking and urethane anesthetized rats.
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步行和乌拉坦麻醉大鼠的海马θ节律和神经元放电。
DOI：
10.1007/bf00236028
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发表时间：
1986
影响因子：
2
通讯作者：
RanckJr,JB
中科院分区：
文献类型：
--
作者：
Fox,SE;Wolfson,S;RanckJr,JB
在行走和乌拉坦麻醉期间，记录取自大鼠海马和齿状回的单个神经元。这些细胞的放电直方图被构建为同时细胞外记录的海马慢波θ节律的相位的函数。注意确保记录θ节律的部位及其相对于可靠参考的相位，以便可以在动物之间进行放电相位的比较。这些神经元中的大多数的放电被深度调制为θ节律的相位的函数。无论θ节律发生在行走期间还是发生在乌拉坦麻醉期间，这都是正确的，但是对于某些类型的细胞，两种θ节律中的平均放电相位是不同的。在行走过程中，锥体细胞和中间神经元在所有海马亚区和齿状颗粒细胞有一个最大的概率发射附近的正峰的θ节律记录在外分子层的齿状（齿状θ）。在乌拉坦麻醉期间，CA1和齿状颗粒细胞的中间神经元的最大放电概率发生在齿状θ的负峰附近，而CA3和CA4的锥体细胞和中间神经元的最大放电相位变得广泛分布。在CA1区锥体细胞的最大放电阶段，如果有的话，更窄分布在周围的正峰的齿状θ在乌拉坦麻醉期间比在行走。行走和乌拉坦麻醉时海马细胞放电的这些差异代表了区分两种海马θ节律的细胞机制的一些差异。
Recordings were taken from single neurons in the hippocampus and dentate gyrus of rats during walking and urethane anesthesia. Firing histograms for these cells were constructed as a function of the phase of the concurrent extracellularly recorded hippocampal slow wave theta rhythm. Care was taken to be sure of the site of recording of the theta rhythm and its phase with respect to a reliable reference, so that comparisons of the phases of firing could be made across animals. The firing of most of these neurons is deeply modulated as a function of the phase of the theta rhythm. This is true whether the theta rhythm occurs during walking or during urethane anesthesia, but for some types of cells the mean phases of firing are different in the two types of theta rhythm. During walking, pyramidal cells and interneurons in all hippocampal subregions and dentate granule cells have a maximum probability of firing near the positive peak of the theta rhythm recorded in the outer molecular layer of the dentate (dentate theta). During urethane anesthesia, the maximum firing probability for interneurons in CA1 and for dentate granule cells occurs near the negative peak of the dentate theta, while the phases of maximum firing for pyramidal cells and interneurons in CA3 and CA4 become widely distributed. The phases of maximum firing of pyramidal cells in CA1 are, if anything, more narrowly distributed around the positive peak of the dentate theta during urethane anesthesia than during walking. These differences in the firing of hippocampal cells during walking and urethane anesthesia represent some of the differences in cellular mechanisms distinguishing two kinds of hippocampal theta rhythm.