Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress
Immunotargeting of catalase to ACE or ICAM-1 protects perfused rat lungs against oxidative stress
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DOI：
10.1152/ajplung.1998.275.4.l806
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发表时间：
1998-10-01
影响因子：
4.9
通讯作者：
Muzykantov, VR
中科院分区：
文献类型：
--
作者：
Atochina, EN;Balyasnikova, IV;Muzykantov, VR
The pulmonary endothelium is susceptible to oxidative insults. Catalase conjugated with monoclonal antibodies (MAbs) against endothelial surface antigens, angiotensin-converting enzyme (MAb 9B9) or intercellular adhesion molecule-1 (MAb 1A29), accumulates in the lungs after systemic injection in rats (V. Muzykantov, E. Atochina, H. Ischiropoulos, S. Danilov and A. Fisher Proc. Natl. Acad. Sci. USA 93: 5213-5218, 1996). The present study characterizes the augmentation of antioxidant defense by these antibody-catalase conjugates in isolated rat lungs perfused for 1 h with catalase conjugated with either MAb 9B9, MAb 1A29, or control mouse IgG. Approximately 20% of the injected dose of Ab-I-125-catalase accumulated in the perfused rat lungs (vs.
