Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis.
Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis.
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DOI：
10.3389/fcell.2015.00075
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发表时间：
2015
影响因子：
5.5
通讯作者：
Ito A
中科院分区：
文献类型：
--
作者：
Yoneshige A;Hagiyama M;Fujita M;Ito A
由粘附分子介导的细胞粘附对于维持组织稳态至关重要。因此，粘附分子表达的改变导致涉及细胞活化、变性和凋亡的各种组织疾病的发生。然而，目前仍不清楚是什么引发了粘附分子表达的改变以及随后的病理级联如何进行。就此而言，细胞粘附分子1（CADM1）是参与病理病变发生发展的候选者之一；它是一种细胞间粘附分子，在肺细胞、神经元和肥大细胞等多种类型的细胞中表达。最近的研究表明CADM1转录或转录后表达的改变与肺部疾病和过敏性疾病的发病机制相关。在这篇综述中，我们特别关注CADM1如何参与肺气肿和特应性皮炎病理病变的发展。
Cell adhesion mediated by adhesion molecules is of central importance in the maintenance of tissue homeostasis. Therefore, altered expression of adhesion molecules leads to the development of various tissue disorders involving cell activation, degeneration, and apoptosis. Nevertheless, it still remains unclear what initiates the altered expression of adhesion molecules and how the subsequent pathological cascades proceed. In this regard, cell adhesion molecule 1 (CADM1) is one of the candidates that is involved in the development of pathological lesions; it is an intercellular adhesion molecule that is expressed in various types of cells such as pulmonary cells, neurons, and mast cells. Recent studies have revealed that alterations in the transcriptional or post-transcriptional expressions of CADM1 correlate with the pathogenesis of pulmonary diseases and allergic diseases. In this review, we specifically focus on how CADM1 is involved in the development of pathological lesions in pulmonary emphysema and atopic dermatitis.