In vitro Activity of FK463, a Novel Lipopeptide Antifungal Agent, against a Variety of Clinically Important Molds
In vitro Activity of FK463, a Novel Lipopeptide Antifungal Agent, against a Variety of Clinically Important Molds
复制标题
FK463（一种新型脂肽抗真菌剂）针对多种临床重要霉菌的体外活性
作者：
T. Nakai;J. Uno;K. Otomo;F. Ikeda;S. Tawara;T. Goto;K. Nishimura;M. Miyaji
采用国家临床实验室标准委员会规定的微量肉汤稀释法M27-A，比较FK463对临床上多种重要机会性霉菌的体外抗真菌活性，与两性霉素B、伊曲康唑和氟康唑进行比较。 FK463 对曲霉菌表现出强大的活性，优于所有其他测试化合物。除某些临床分离株外，FK463 对深色真菌毛状枝孢菌 (Cladosporium trichoides)、Exophiala spinifera、Fonsecaea pedrosoi 和 Exophiala dermatitidis 也有活性。然而，FK463 对茄病镰刀菌、波氏假菌和接合菌 Absidia corymbifera、Cunninghamella elegans、Rhizopus oryzae 和 Rhizopus microsporus var. 没有活性。根足形。这些结果表明 FK463 具有治疗曲霉属和暗色真菌引起的感染的潜在用途。
The in vitro antifungal activity of FK463 against a variety of clinically important opportunistic molds was compared with amphotericin B, itraconazole and fluconazole by using the broth microdilution method M27-A specified by the National Committee for Clinical Laboratory Standards. FK463 exhibited potent activity against Aspergillus species, which was superior to those of all other compounds tested. FK463 was also active against the dematiaceous fungi Cladosporium trichoides, Exophiala spinifera, Fonsecaea pedrosoi, and Exophiala dermatitidis except for certain clinical isolates. However, FK463 had no activity against Fusarium solani, Pseudallesheria boydii, and the zygomycetes Absidia corymbifera, Cunninghamella elegans, Rhizopus oryzae, and Rhizopus microsporus var. rhizopodiformis. These results suggest that FK463 has potential utility for the treatment for infections caused by Aspergillus species and dematiaceous fungi.
DOI：
10.1093/clinids/13.6.1077
发表时间：
1991
期刊：
Reviews of infectious diseases
影响因子：
--
作者：
Gamis,AS;Gudnason,T;Giebink,GS;Ramsay,NK
通讯作者：
Ramsay,NK