Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men
Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men
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DOI：
10.1210/jc.2004-1501
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发表时间：
2005-03-01
影响因子：
5.8
通讯作者：
Lee, KO
中科院分区：
文献类型：
--
作者：
Liew, CF;Wise, SD;Lee, KO
我们使用正常血糖高胰岛素钳夹技术研究了不同种族（亚洲印度人、中国人和高加索人）中IGF结合蛋白（IGFBP）-1、胰岛素敏感性和瘦素之间的关系。研究对象为10名健康、年轻、非糖尿病的受试者，他们来自各个种族，体重指数、年龄和体力活动相匹配。对所有受试者进行正葡萄糖钳夹。在禁食后和钳夹期间测量IGFBP-1、胰岛素和瘦素。中国人空腹IGFBP-1浓度最高（P = 0.027）。亚裔印度人的胰岛素敏感性指数最低（P = 0.006）。在空腹和整个正常血糖钳夹试验中，亚洲印度人的胰岛素与IGFBP-1的比例较高。空腹IGFBP-1水平与空腹瘦素水平呈显著负相关（r =-0.715，P = 0.001）。多元线性回归分析显示，空腹胰岛素、瘦素、种族和胰岛素敏感性是空腹IGFBP-1的重要预测因子。IGFBP-1是独立决定的种族，胰岛素敏感性，瘦素在葡萄糖耐受的男性。亚裔印度人存在相对胰岛素抵抗和空腹IGFBP-1水平较低，可能导致他们患糖尿病和心血管疾病的风险较高。
We examined the relationships among IGF binding protein ( IGFBP)-1, insulin sensitivity, and leptin in different ethnic groups ( Asian Indians, Chinese, and Caucasians) using the euglycemic hyperinsulinemic clamp. Ten healthy, young and nondiabetic subjects of each ethnic group, matched for body mass index, age, and physical activity were studied. A euglycemic clamp was performed on all subjects. IGFBP-1, insulin, and leptin were measured after fasting and during the clamp. Fasting IGFBP-1 concentration was highest in Chinese ( P = 0.027). Asian Indians had the lowest insulin sensitivity index ( P = 0.006). The ratio of insulin to IGFBP-1 at fasting and throughout the euglycemic clamp was higher in Asian Indians. Fasting IGFBP-1 had a strong negative correlation with fasting leptin levels ( r = - 0.715, P = 0.001). Multiple linear regression demonstrated that fasting insulin, leptin, ethnicity, and insulin sensitivity were significant predictors for fasting IGFBP-1. IGFBP-1 is independently determined by ethnicity, insulin sensitivity, and leptin in glucose-tolerant men. The presence of relative insulin resistance and low fasting IGFBP-1 levels in Asian Indians may contribute to their higher risk of developing diabetes and cardiovascular disease.