Release of Histamine from Mast Cells by Vasoactive Peptides 1
Release of Histamine from Mast Cells by Vasoactive Peptides 1
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血管活性肽 1 从肥大细胞释放组胺
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
E. G. Erdös
中科院分区：
文献类型：
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作者：
A. Johnson;E. G. Erdös
摘要研究了多种合成肽对大鼠肥大细胞的影响。具有两个或两个以上碱性基团的多肽是活性组胺释放剂，而肾上腺素、血管紧张素I和II、胰升糖素和纤维蛋白O肽A具有轻微或没有活性。缓激肽类似物的活性随着链长的增加而增加。缓激肽的去精氨酸衍生物不释放组胺。最强的组胺解除剂是P物质和Polistes激肽，后者的活性接近48/80。由于激肽可以在不破坏肥大细胞膜的情况下释放组胺，这些药物如48/80可能刺激肥大细胞颗粒的胞吐。
Summary The effect of a variety of synthetic peptides on rat mast cells was investigated. Peptides with two or more basic groups were active histamine releasers, while eledoisin, angiotensin I and II, glucagon, and fibrinOpeptide A had slight or no activity. The activity of bradykinin analogues increased with the chain length. Des-arginine derivatives of bradykinin did not release histamine. The most potent histamine liberators were substance P and Polistes kinin; the activity of the latter one approached that of 48/80. Because histamine could be released by the kinin peptides without disruption of the mast cell membrane, these agents like 48/80, probably stimulate exocytosis of mast cell granules.