Innovation - Detection and interpretation of altered methylation patterns in cancer cells
Innovation - Detection and interpretation of altered methylation patterns in cancer cells
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DOI：
10.1038/nrc1571
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发表时间：
2005-03-01
影响因子：
78.5
通讯作者：
Ushijima, T
中科院分区：
文献类型：
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作者：
Ushijima, T
表观遗传改变，如异常的DNA甲基化模式，与许多人类肿瘤类型有关。已经开发了新的技术来对DNA甲基化模式的变化进行全基因组筛查，不仅是为了识别肿瘤抑制基因，而且还为了找到可以用于诊断和预后的模式。然而，对差异甲基化的解释已经被证明是困难的，因为甲基化改变的意义取决于基因组区域，而CpG岛在特定位置的功能还没有完全阐明。哪些技术可以用来识别新的肿瘤抑制因子和诊断标志物？
Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with many human tumour types. New techniques have been developed to perform genome-wide screening for alterations in DNA-methylation patterns, not only to identify tumour-suppressor genes, but also to find patterns that can be used in diagnosis and prognosis. However, interpretation of differential methylation has proven difficult because the significance of methylation alterations depends on the genomic region, and functions of CpG islands at specific sites have not been fully clarified. What techniques can be used to identify new tumour suppressors and diagnostic markers?