Sharing of antigenic determinants between the nicotinic acetylcholine receptor and proteins in Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae. Possible role in the pathogenesis of myasthenia gravis.
Sharing of antigenic determinants between the nicotinic acetylcholine receptor and proteins in Escherichia coli, Proteus vulgaris, and Klebsiella pneumoniae. Possible role in the pathogenesis of myasthenia gravis.
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DOI：
10.1056/nejm198501243120407
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发表时间：
1985-01
期刊：
影响因子：
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通讯作者：
K. Stefansson;M. Dieperink;D. Richman;C. Gomez;L. Marton
中科院分区：
文献类型：
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作者：
K. Stefansson;M. Dieperink;D. Richman;C. Gomez;L. Marton
人类自身免疫性疾病的原因在大多数情况下是未知的。然而，关于在自身免疫过程中对自身抗原的免疫攻击可能是什么原因，有无数的假设。其中一些假设涉及感染因子。一个流行的观点是，许多自身免疫性疾病可能是由病毒感染直接或间接引起的。1，2病毒可能通过改变宿主的免疫系统，通过引起隔离抗原的释放或表达，或通过病毒和宿主细胞共享的抗原决定簇来启动自身免疫过程。现在有相当多的证据表明，抗原决定簇是共享的。. .
THE causes of autoimmune diseases in human beings are in most instances unknown. There are, however, countless hypotheses about what may be responsible for an immunologic attack on autoantigens during autoimmune processes. Some of these hypotheses involve infectious agents. One popular notion is that many autoimmune diseases may be caused directly or indirectly by viral infections.1 , 2 Viruses may launch autoimmune processes by altering the host's immune system, by causing the release or expression of sequestered antigens, or through antigenic determinants shared by the virus and the host cells. There is now considerable published evidence that antigenic determinants are shared by . . .