Gas-phase chiral separations by ion mobility spectrometry
Gas-phase chiral separations by ion mobility spectrometry
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DOI：
10.1021/ac0608772
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发表时间：
2006-12-15
影响因子：
7.4
通讯作者：
Hill, Herbert H., Jr.
中科院分区：
文献类型：
--
作者：
Dwivedi, Prabha;Wu, Ching;Hill, Herbert H., Jr.
本文介绍了手性离子迁移谱（CIMS）的概念，并举例说明了手性离子迁移谱（CIMS）用于药物、氨基酸和碳水化合物等多种外消旋体的气相分离。CIMS类似于传统的离子迁移谱，其中气相离子在经受电位梯度时由于其形状和尺寸的差异而在大气压下分离。除了尺寸和形状之外，CIMS还基于离子与手性气体的立体特异性相互作用来分离离子。为了实现CIMS手性识别，通过在漂移气体中掺杂挥发性手性试剂来提供非对称环境。在这项研究中，（S）-（+）-2-丁醇被用作手性改性剂，以证明阿替洛尔，丝氨酸，蛋氨酸，苏氨酸，甲基α-吡喃葡萄糖苷，葡萄糖，青霉胺，缬氨醇，苯丙氨酸和色氨酸从其各自的外消旋混合物的对映体分离。
This article introduces the concept of chiral ion mobility spectrometry (CIMS) and presents examples demonstrating the gas-phase separation of enantiomers of a wide range of racemates including pharmaceuticals, amino acids, and carbohydrates. CIMS is similar to traditional ion mobility spectrometry, where gas-phase ions, when subjected to a potential gradient, are separated at atmospheric pressure due to differences in their shapes and sizes. In addition to size and shape, CIMS separates ions based on their stereospecific interaction with a chiral gas. In order to achieve chiral discrimination by CIMS, an asymmetric environment was provided by doping the drift gas with a volatile chiral reagent. In this study (S)-(+)-2-butanol was used as a chiral modifier to demonstrate enantiomeric separations of atenolol, serine, methionine, threonine, methyl alpha-glucopyranoside, glucose, penicillamine, valinol, phenylalanine, and tryptophan from their respective racemic mixtures.