Dual Catalysis in Rhodium(II) Carbenoid Chemistry
Dual Catalysis in Rhodium(II) Carbenoid Chemistry
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铑(II)类胡萝卜素化学中的双重催化
DOI：
10.1002/ejoc.202101419
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发表时间：
2022
影响因子：
2.8
通讯作者：
Sharma, Indrajeet
中科院分区：
文献类型：
--
作者：
Bain, Anae I.;Chinthapally, Kiran;Hunter, Arianne C.;Sharma, Indrajeet
双催化代表了一种替代原型，在碳化学超越传统的单一催化剂系统。通过采用双催化剂系统，人们可以提高现有反应的效率，并实现新的化学转化。涉及双协同催化的反应越来越有价值，因为它们为合成具有挑战性的季碳中心和生物活性核心结构提供了方便的策略。这篇综述文章的重点是捕获重氮衍生的铑（II）两性离子中间体，这些中间体具有不同的亲电试剂，如Michael受体、炔、π -烯丙基Pd（II）配合物和Nicholas中间体。
Dual catalysis represents an alternative archetype in carbene chemistry that surpasses traditional single catalyst systems. By employing dual catalyst systems, one can improve the efficiency of existing reactions and enable new chemical transformations. Reactions involving dual synergistic catalysis are increasingly valuable as they offer convenient strategies for synthesizing challenging quaternary carbon centers and bioactive core structures. This review article focuses on trapping diazo‐derived, rhodium (II) zwitterionic intermediates with varying electrophiles such as Michael acceptors, alkynes, π‐allyl Pd(II) complexes, and the Nicholas intermediate.