The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition.
The evaluation of brain perfusion SPECT using an easy Z-score imaging system in the mild cognitive impairment subjects with brain amyloid-β deposition.
复制标题
使用简单的 Z 评分成像系统对患有脑淀粉样蛋白-β 沉积的轻度认知障碍受试者进行脑灌注 SPECT 评估。
DOI：
10.1016/j.clineuro.2017.06.018
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Matsubara E
中科院分区：
文献类型：
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作者：
Takemaru M;Kimura N;Abe Y;Goto M;Matsubara E
目的利用Easy Z-Score成像系统(EZIS)程序对99mTc-ECD单光子发射计算机断层扫描(SPECT)图像进行分析，为日常医疗实践中早期AD的诊断提供依据。然而，目前还不清楚eZIS分析是否能识别有脑淀粉样蛋白β沉积的遗忘性轻度认知障碍患者。本研究的目的是评价eZIS分析在预测有脑淀粉样蛋白β沉积的遗忘型多发性脑梗塞患者中的有效性。将MCI患者分为PIB阳性亚组和PIB阴性亚组。使用eZIS程序的感兴趣特定体积分析程序分析SPECT数据。自动计算三项指标(严重程度、程度和比率)，并在两个亚组之间进行比较。
Objective The analysis of 99mTc-ECD single-photon emission computed tomography (SPECT) images using the easy Z-score imaging system (eZIS) program is useful for the diagnosis of early AD in daily medical practice. However, it remains unclear whether eZIS analysis can identify the amnestic mild cognitive impairment (MCI) subjects with brain amyloid-β deposition. The aim of this study was to evaluate the usefulness of an eZIS analysis for predicting amnestic MCI subjects with brain amyloid β deposition.Patients and Methods Twenty-three subjects with MCI (10 men and 13 women, mean age; 74.2 years) underwent brain perfusion SPECT and PiB-PET. MCI subjects were classified into PiB-positive and PiB-negative subgroups. SPECT data was analyzed using the Specific Volume of interest Analysis of the eZIS program. Three indicators (severity, extent, and ratio) were calculated automatically and compared between the two subgroups.