EVALUATION OF THE HEALING ACTIVITY OF PEQUI (CARYOCAR CORIACEUMWITTM) OIL IN CUTANEOUS WOUNDS INDUCED EXPERIMENTALLY IN RATS
EVALUATION OF THE HEALING ACTIVITY OF PEQUI (CARYOCAR CORIACEUMWITTM) OIL IN CUTANEOUS WOUNDS INDUCED EXPERIMENTALLY IN RATS
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DOI：
10.1590/1808-1657v77p4412010
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发表时间：
2010-09-01
期刊：
影响因子：
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通讯作者：
Olinda, R.G.
中科院分区：
文献类型：
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作者：
Batista, J.S.;Silva, A.E.;Olinda, R.G.
皮肤油对实验性大鼠皮肤创面愈合作用的评价本研究的主要目的是用40只60日龄雄性Wistar品系的褐家鼠(Rattus Norveicus Albinus)进行局部涂抹含胡椒油软膏(Caryocar Coriaceum WiTTM)的效果。这些受试者被分为两组：i)由20只皮肤创伤的小鼠组成，局部涂抹基于10%pequi油的软膏；ii)相同数量的小鼠，接受不含pequi油的软膏的局部涂抹。在消毒和局部麻醉后，在下背部制作直径为1 cm的圆形创面。分别于术后第3、7、14、21天对创面进行临床、形态和组织学评价。用pequi软膏治疗的那一组在愈合过程中表现出加速。从术后第14天开始，该组动物的创面明显减少，从愈合过程结束时开始观察到组织学特征，如大量的成纤维细胞、胶原纤维和完整的再上皮化过程，而对照组的创面需要更多的时间才能愈合。
EVALUATION OF THE HEALING ACTIVITY OF PEQUI (CARYOCAR CORIACEUM WITTM) OIL IN CUTANEOUS WOUNDS INDUCED EXPERIMENTALLY IN RATS. The main objective of this study was to demonstrate the effects of topical treatment with ointment containing pequi oil (Caryocar coriaceum Wittm), using 40 male 60-day-old mice (Rattus norvegicus albinus) from the Wistar line. These were divided into two groups: I) composed by 20 mice with cutaneous wounds treated by topical application of the ointment based on 10% pequi oil; II) the same number of mice, receiving the topical application of ointment without pequi oil. After antisepsis and local anesthesia, round 1-cm-diameter wounds were made on the lower back region. The wounds were evaluated in regard to clinical, morphometric and histological aspects on the 3rd, 7th, 14th and 21st postoperative days. The group treated with the pequi ointment presented acceleration in the healing process. The animals' wounds of this group showed a meaningful reduction from the 14th postoperative day, when histological characteristics from the ending of the healing process were noted, such as a large amount of fibroblasts, collagen fibers and a complete process of reepithelialization, while the wounds of the control group needed more time for the healing process.